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KMID : 0360219720130010011
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Journal of the Korean Ophthalmological Society
1972 Volume.13 No. 1 p.11 ~ p.16
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The effects of adrenergic and adrenergic blocking agents on the phosphorylase activity of bovine extraocular muscles
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Abstract
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The author investigated the effect of adrenergic and adrenergic blocking agents on the phosphorylase activity of bovine extraocular muscle in vitro and obtained the following results:
1. The phosphorylase a activity of bovine extraocular muscle was revealed 5&.6%´ in vitro.
2 The phosphorylase a activity of bovine extraocular muscle was slightly enhanced by the adrenergic agents such as epinephrine, norepinephrine and isoproterenol.
3. The phosphorylase a activity of bovine extr$ocular muscle was not affected -by the adrenergic areceptor blocking agent, phenoxybenzamine but slightly inhibited by the adrenergic (i-receptor blocking agent, propranolol.
4. The phosphorylase a activity of bovine extraocular muscle previously treated with the adrenergic agents was blocked by a sole administration of propranolol or combined administrations of propranolol and phenoxybenzamine but not blocked by phenoxybenzamine alone.
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